SYNTHESIS OF HEXA-PEPTIDE ANALOGUES TO OPTIMIZE CELL DISRUPTION
Erik Bautista, Scott Lokey, Andrew Bockus, Alexandra Ponkey.
University of California, Santa Cruz, Santa Cruz, CA.
Cyclic peptides naturally occur in plants, fungi, and animals and have the potential to treat diseases. The purpose of this project is to optimize the bioactivity of a cyclic hexa-peptide that is known to disrupt cell division in certain cells. A set of side chain analogues will be synthesized using solid-phase peptide synthesis. The synthetic products will be analyzed by mass spectrometry, and their biological activity will be assessed in HeLa cells. Based on these results, a strategy will be developed to improve cyclic peptides as drug candidates by changing non-essential side chain amino acids and observing the effects on the disruption of the cell cycle. The outcomes will help future efforts toward improving this drug scaffold.